追隨 Dr Folkman...

本實驗室最近有一篇關於VEGF PTEN 對微血管網發育的報告被接受
其中有兩篇參考文獻是出自 Dr Folkman 的

"佛克曼醫生的戰爭"(本實驗室的指定讀物),this book inspires me when I have no idea about my research direction...

The Open Zoology Journal
ISSN: 1874-3366 Volume 1, 2008
http://www.bentham.org/open/tozj/index.htm

Correlation between PTEN and VEGF expressions during the development of gas gland in Japanese eel (Anguilla japonica) stimulated by exogenous hypophyseal factors.

Yi-Fan Chen1, Shan-Ru Jeng2, Ming-Chyuan Chen3, Jin-Chywan Gwo4, Yung-Sen Huang5*

Abstract
Organogenesis requires support of the vascular system and control of proliferation activity. VEGF, a selective mitogen for vascular endothelial cells, is important for vessel development. PTEN, known as a tumor suppressor, regulates cell size and modulates VEGF-mediated signaling on angiogenesis. However, it is not yet clear if PTEN controls tissue mass by suppressing angiogenesis provoked by VEGF and their correlations in postnatal tissue development in vivo. We used a primitive vertebrate, Japanese eel (Anguilla japonica), to study this question. Swim bladder gas glands (a somatic tissue composed mainly by the capillaries) from normal eels or eels injected with hypophyseal factors were used to examine the expression of VEGF A, PTEN, IGF-1, and Flk-1 by RT-PCR. Two forms of PTEN (PTEN a, long form, and PTEN b, short form) cDNA have been cloned. There was no correlation between VEGF expression and gas gland tissue mass while a negative correlation between PTEN expression and tissue mass was noted; further, a higher correlation between the tissue mass and the ratio of VEGF to PTEN was shown. In summary, we have shown the involvement of VEGF and PTEN in postnatal tissue development, the ratio of VEGF to PTEN may represent the growth status of the tissue.